The PLAC® Test for Lp-PLA2 activity measures the function of Lp-PLA2 in the artery wall— a vascular-specific inflammatory marker critical in the formation of rupture-prone plaque. Lp- PLA2 activity is a novel risk predictor in people with no prior history of cardiovascular events with a prognostic value independent of standard lipid profile testing. The greater the Lp-PLA2 Activity, the greater the risk of fatal and non-fatal coronary heart disease (CHD) events. A PLAC test may sometimes be used along with an hs-CRP test to evaluate a person’s level of underlying inflammation associated with Cardiovascular Disease (CVD) risk. However, unlike hs-CRP, the PLAC test is not affected by conditions other than CVD that can cause general inflammation, so it may be used when someone has an inflammatory condition, such as arthritis.

Oxidized LDL

Oxidized LDL is LDL cholesterol (the “bad” cholesterol) that has been modified by oxidation. Oxidized LDL triggers inflammation leading to the formation of plaque in the arteries, also known as atherosclerosis. Oxidized LDL may also play a role in increasing the amount of triglycerides the body produces, as well as increasing the amount of fat deposited by the body. In turn, fat tissue can enhance the oxidation of LDL, creating a vicious cycle.

Myeloperoxidase (MPO) enzyme is found in neutrophil primary granules and monocyte lysosomes. MPO catalyzes the conversion of hydrogen peroxide to hypochlorite and hypochlorous acid. MPO is encoded by a single gene that undergoes posttranslational modification to produce the active enzyme found in leukocytes.


  • Draw from a vein into a SST tube.
  • Invert tube (do not shake) 1-2 times to mix adequately.
  • Let it stand upright in tube rack for 30 minutes and centrifuge for 15 minutes at 3300 rpm
  • Do not leave at room temperature for more than 1 hour.
  • Keep cold in a refrigerator to maintain stability, until ready to ship.
  • Freeze ice packs 24 hours prior to use
  • Place ice packs inside the Styrofoam insulated kit
  • Place processed tubes inside biohazard bag, place inside kit
  • Seal box, print airbill and adhere to box and wait for courier to pick up.

Additional information

Weight 0.55 kg