Folate Metabolism; plasma


This test measures the levels of the primary forms of folate (B-9) in plasma, and can be used to assess folate status and disorders in essential folate metabolism. Assessment of plasma folate species provides clinical insight into aberrant folate metabolism that can significantly affect crucial methylation processes, DNA/RNA metabolism, and neurotransmitter metabolism. Naturally occurring folates are derived mostly from dark green leafy vegetables while synthetic folic acid is used under mandate in cereals and other processed foods. There is debate regarding synthetic folic acid as it is not considered biologically active unless converted into activated folates, and can block folate metabolism. Reduced activated forms of folate are obligatory cofactors in the metabolism of amino acids and DNA. Traditionally long-term folate status is determined as the level of total folates in red blood cells, but that does not provide clinically important information regarding the specific forms of folate. The plasma folate profile reports the levels of THF, UMFA, folinic acid and 5-MTHF, and can be used to monitor clinical intervention. It can be used as a single test, or as a basal and one hour post-folate supplement “challenge.” It can also be a useful add on to the functional Plasma Methylation Profile.

This test is useful for

• Prenatal Care
• Folate Receptor Autoantibodies
• Nutrutional Deficiencies
• Elevated Homocysteine
• Cardiovascular Disease
• Neurotransmitter Imbalances
• Autism
• Cancer/Chemotherapy
• Detoxification Impairment
• General Health and Longevity
• Genetic Disorders
• Assess functional folate metabolism in variants of MTHFR and COMT
• Assess therapeutic interventions of enzymatic deficienes of methylation
• Neurodegenerative Diseases
• Psychiatric Disorders
• Behavioral Disorders


Additional information

Weight 0.55 kg