Showing all 4 results

    CardioGenomicPlus™ Profile

    $535.00

    The CardioGenomic Plus™ Profile uses genomic testing to identify the risk of genetic susceptibility to cardiac related diseases and conditions. Specifically, the CardioGenomic Plus™ Profile evaluates genetic variations, called single nucleotide polymorphisms (SNPs) in genes that modulate blood pressure regulation, lipid balance, nutrient metabolism, inflammation, and oxidative stress.

    This test uncovers potential genetic susceptibility to:

    • Hypercholesteremia
    • Atherosclerosis
    • Obesity
    • Hypertension
    • Myocardial infarction
    • Thrombosis
    • Endothelial dysfunction
    • Stroke

    Cholesterol Regulation and Atherosclerosis

    • ApoE (apolipoprotein E)
    • CETP (cholesteryl ester transfer protein)
    • SELE (selectin E)

    These genes affect how the body breaks down and clears fats and how cholesterol is processed. They also affect lipid balance, plaque formation, and blood vessel integrity and function.

    Methylation

    • MTHFR (methylenetetrahydrofolate reductase)

    Polymorphisms of this enzyme can disrupt the metabolism of homocysteine, resulting in its accumulation as well as impaired methylation. The presence of these SNPs can increase risk of cardiovascular disease, blood vessel damage, thrombosis (blood clots), stroke, and degenerative aging.

    Hypertension

    • GNB3 (guanine nucleotide-binding protein)
    • AGTR1 (angiotensin II receptor-1)

    Polymorphisms of these genes are associated with blood vessel constriction, sodium and water retention, obesity, and increased susceptibility to hypertension.

    Coagulation

    • Factor 2 (prothrombin)
    • Factor 5 (Leiden)
    • PAI-1 (Plasminogen activator inhibitor-1)
    • GP3a (Glycoprotein 3)

    These genetic variants can over-activate blood clotting processes, increasing the risk of sudden cardiac events such as thrombosis, heart attacks, and strokes.

    CardioGenomicPlus™ Profile

    $535.00

    The CardioGenomic Plus™ Profile uses genomic testing to identify the risk of genetic susceptibility to cardiac related diseases and conditions. Specifically, the CardioGenomic Plus™ Profile evaluates genetic variations, called single nucleotide polymorphisms (SNPs) in genes that modulate blood pressure regulation, lipid balance, nutrient metabolism, inflammation, and oxidative stress.

    This test uncovers potential genetic susceptibility to:

    • Hypercholesteremia
    • Atherosclerosis
    • Obesity
    • Hypertension
    • Myocardial infarction
    • Thrombosis
    • Endothelial dysfunction
    • Stroke

    Cholesterol Regulation and Atherosclerosis

    • ApoE (apolipoprotein E)
    • CETP (cholesteryl ester transfer protein)
    • SELE (selectin E)

    These genes affect how the body breaks down and clears fats and how cholesterol is processed. They also affect lipid balance, plaque formation, and blood vessel integrity and function.

    Methylation

    • MTHFR (methylenetetrahydrofolate reductase)

    Polymorphisms of this enzyme can disrupt the metabolism of homocysteine, resulting in its accumulation as well as impaired methylation. The presence of these SNPs can increase risk of cardiovascular disease, blood vessel damage, thrombosis (blood clots), stroke, and degenerative aging.

    Hypertension

    • GNB3 (guanine nucleotide-binding protein)
    • AGTR1 (angiotensin II receptor-1)

    Polymorphisms of these genes are associated with blood vessel constriction, sodium and water retention, obesity, and increased susceptibility to hypertension.

    Coagulation

    • Factor 2 (prothrombin)
    • Factor 5 (Leiden)
    • PAI-1 (Plasminogen activator inhibitor-1)
    • GP3a (Glycoprotein 3)

    These genetic variants can over-activate blood clotting processes, increasing the risk of sudden cardiac events such as thrombosis, heart attacks, and strokes.

    EstroGenomic® Profile

    $710.00

    The EstroGenomic® Profile uses genomic testing to identify susceptibility to diseases and conditions such as breast cancer, osteoporosis, and heart disease. More specifically, the EstroGenomic® Profile evaluates genetic variations, called single nucleotide polymorphisms (SNPs) in genes that modulate estrogen metabolism, coagulation, cardiovascular function, bone health, and inflammation.

    The EstroGenomic® test uncovers potential genetic susceptibility to diseases and conditions such as:

    • Breast cancer
    • Osteoporosis
    • Thrombosis
    • Strokes
    • Atherosclerosis
    • Heart Disease

    Specialized genomic testing from Genova Diagnostics can provide a glimpse into ones potential health future.

    Genetic testing enables one to minimize the risk by:

    • Identifying hidden gene mutations that may promote chronic disease
    • Preventing disease through early intervention
    • Modifying gene expression through more precise, targeted, individualized interventions
    • Identifying key areas for follow-up testing
    • Monitoring therapeutic effectiveness of intervention strategies with laboratory testing

    Whether or not you choose to see genes, they are always there and will continue to play an important role in one’s health.  With genomic testing, by choosing to look at them, you have the opportunity to influence the ultimate outcome and more actively promote a healthy life. The EstroGenomic® Profile evaluations include:

    Estrogen Metabolism

    • CYP1A1
    • GST (M1 and P1)
    • CYP1B1
    • COMT (catechol-O-methyl transferase)

    Estrogen metabolism SNPs focus on the Phase 1 enzymes involved in the formation of anti- or procarcinogenic metabolites such as 2-hydroxyestrone and 4-hydroxyestrone, respectively, as well as the Phase 2 enzymes responsible for the subsequent metabolism of these compounds. Levels of the various estrogen metabolites modulate risk of both breast cancer and osteoporosis.

    HyperCoagulation

    • GP3a (Glycoprotein 3)
    • Factor 2 (Prothrombin)
    • PAI-1 (Plasminogen activator inhibitor-1)
    • Factor 5 (Leiden)

    These genetic variants focus on estrogens interaction with some of the key constituents of the clot formation and fibrinolysis process, such as clotting factors and inhibitors of fibrinolysis. The SNPs can over-activate blood clotting processes, increasing the risk of sudden cardiac events such as thrombosis, heart attacks, and strokes, especially among women take supplemental estrogens and oral contraceptives.

    Cardiovascular

    • Apo E (apoliprotein E)
    • TNF-a
    • MTHFR
    • IL-6

    These genes affect how the body processes cholesterol, responds to inflammation, and metabolizes B vitamins. The presence of these SNPs can increase risk of cardiovascular disease, hyperlipidemia, and blood vessel damage.

    Osteoporosis

    • VDR
    • TNF-a
    • IL-6

    Osteoporosis SNPs relate to estrogens influence on inflammation, bone resorption, vitamin D function and bone collagen formation.

    Test Type: Saliva Test

    ImmunoGenomic® Profile

    $710.00

    This test evaluates genetic variations in genes that modulate immune and inflammatory activity. These variations can affect balance between cell (Th-1) and humoral (Th-2) immunity, trigger potential defects in immune system defense, and stimulate mechanisms underlying chronic, overactive inflammatory responses.